Best Acne Spot Treatments

Sephora customers often prefer the following products when searching for Best Acne Spot Treatments.

Acne is be a pesky and stubborn skin concern that many of us have experienced at some point in our lives. Whether it's a sudden breakout or a lingering blemish, finding an effective spot treatment is crucial for targeting those unwelcome visitors. We understand the frustration and the desire to find the best acne spot treatments that deliver quick and noticeable results. That's why we've curated a comprehensive list of acne-fighting products, so you can confidently choose the treatment that suits your skin needs. From powerful ingredients to innovative formulations, we'll explore the top options available to help you bid farewell to those pesky pimples and regain your confidence.

$14.00

This is honestly the best acne spot treatment out there. I’ve tried a lot of spot treatments, like the hydrocolloid patches, and this is better. ...It's not drying like some of the other acne spot treatments. It goes on really smoothly and you just need the tiniest of amounts. ...Best Acne Spot Treatment!

What it is: A non-drying, gentle, and targeted acne treatment that clears acne spots fast while layering under makeup without flaking.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Pores, Redness, Acne and Blemishes


Highlighted Ingredients:
- 2% Succinic Acid: Visibly reduces blemish size and absorbs excess oil.

- 2% Sulfur Powder: Absorbs excess oil and unclogs pores for clearer-looking skin—long term.

- 1% Salicylic Acid: Gently exfoliates the skin, reducing dead-skin cell buildup.


Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

Mario BadescuDrying Lotion

Size: 1 oz/ 29 mL·ITEM: 2184992

Type: Original

446 Reviews

$18.00

Good spot treatment for acne prone normal/dry skin...Really great for spot treatments! Gets zits down to a manageable size overnight....FAVORITE SPOT TREATMENT...It dries your acne spot without irritating or drying your skin.

What it is: An original, award-winning solution that dries up surface blemishes overnight.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Liquid

Highlighted Ingredients:
- Salicylic Acid: Exfoliates to help shed pore-clogging dead skin cells.
- Sulfur: Cleanses pores and absorbs excess oil.
- Calamine: Delivers a cooling, soothing effect.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, formaldehydes, formaldehyde-releasing agents, phthalates, mineral oil, retinyl palmitate, oxybenzone, coal tar, hydroquinone, triclosan, and triclocarban, and contains less than one percent of synthetic fragrances.

$34.00

One of the best Spot treatments ever!...One of the best Spot treatments ever!!! I also use Mario Badescu drying lotion which is also amazing!!! ...Best spot treatment!...I am IN LOVE with this! I have used other acne spot treatments and all they did was dry out the spot and leave the blemish.

What it is: A topical formula for breakouts with results as good as a leading prescription.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Acne and Blemishes

Formulation: Lightweight Gel

Highlighted Ingredients:
- Salicylic Acid: Clears dead skin cells that can contribute to clogged pores.
- Witch Hazel: Minimizes shine on the skin‘s surface and tightens the appearance of pores.
- Laminaria Saccharina Extract: Helps decrease oil buildup that can lead to breakouts.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates. This product is also gluten-free.

What Else You Need to Know: This formula with salicylic acid helps clear th

$56.00

Drying aside I do notice a difference with this product and keep it around as I like to rotate spot treatments since they often times can stop working. ...It works for my acne spot.

What it is: A five percent benzoyl-peroxide-based treatment that targets pores to diminish the appearance of existing blemishes and blackheads, and absorb excess oil.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Uneven Texture, Acne and Blemishes, and Oiliness

Formulation: Lightweight Lotion

Highlighted Ingredients:
- Five Percent Benzoyl Peroxide: Helps diminish the look of blemishes.
- Advanced Liposomes: Help protect skin from environmental aggressors, alleviate dryness, and prevent excess water loss.
- Argan, Saw Palmetto, and Sesame Seed Extracts: Absorb excess oil.

Ingredient Callouts: Free of sulfates SLS and SLES, parabens, and phthalates.

$20.00

I've been using this for years. Simply THE best acne spot treatment around....Dries pimple quicker than other treatments I’ve tried before. It is a bit pricey for the size but it is the same for other acne spot treatments.

What it is: An acne treatment gel with 1.5% Salicylic Acid for on-the-spot, targeted treatment––wherever you go.


Skin Type: Normal, Dry, and Oily


Skincare Concerns: Acne and Blemishes, Redness, and Oiliness


Formulation: Gel


Highlighted Ingredients:

- Saw Palmetto: Helps control oil, reduce shine, and prevent breakouts.


What Else You Need to Know: This blemish-fighting formula with saw palmetto and 1.5 percent salicylic acid helps eliminate excess oil that can lead to break outs.

$19.00

Best acne spot treatment I have ever used!...Better than any other acne spot treatments I've used!...I’ve used plenty of different acne spot treatments, and always end up coming back to these dots!

What it is: The only patented acne patch that combines clean hydrocolloid polymer technology and actives to minimize the look of pimples overnight.

$18.00

this has been on of the only spot treatments that has worked for my acne!...It works! One of the few acne spot treatments I’ve tried that works! A bonus is that it doesn’t leave the blemish dry and flaky.

What it is: A fast-acting blemish spot treatment that zaps pimples overnight with zero irritation and helps brighten the look of spots from past breakouts.

Skin Type:
Normal, Dry, Combination, and Oily

Skincare Concerns: Acne/Blemishes and Oiliness

Highlighted Ingredients:
- Clay and Sulfur: Absorb excess oil and balance sebum production.
- Willow Bark: Nature's alternative to salicylic acid, it helps calm breakouts and clear pores.
- Azelaic Acid: Helps prevent spots left by past blemishes.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

Peace OutSalicylic Acid Acne Day Dots

ITEM: 2644128

Size: 1 pack / 20 dots

1.3K Reviews

$20.00

Just your basic acne spot treatments. I like that you wear them overnight and they do seem to make a difference!...A must have for my acne spot treatments...After a few weeks of using it, I did notice a slight difference on my acne when it started to occur on my chin. This is a must have in your acne treatment bag.

What it is: Our thinnest, sheer acne patch for virtually invisible wear, alone or under makeup, with acne-fighting actives to minimize the look of pimples

OLEHENRIKSENPout Preserve Hydrating Peptide Lip Treatment

Size: 0.4 oz / 12 ml·ITEM: 2814317

Color: Citrus Sunshine Glimmer

1.6K Reviews

$22.00

Absolute Best Lip Treatment on the Market...This is so good you will want to throw out your other lil treatments! Lasts a long time and truly improves the integrity of your lips over time. ...best lip treatment out there...i’m a lippie fanatic and own all sorts of lip products. i wholeheartedly recommend this product over summer fridays and other lip treatments. this peptide treatment is more nourishing and lasts longer than most products.

What it is: An advanced lip treatment with skin-supporting peptides and kokum butter that quickly, visibly plumps lips with hydration and smooths fine lines.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Dryness, and Loss of Firmness and Elasticity


Shade Description: 

- Citrus Sunshine: Sheer tint with a fresh citrus scent.

- Cocoa Crème: Chocolate brown tint with a rich hot cocoa scent.

- Strawberry Sorbet: Mauve pink tint with a freshly picked strawberry scent.

- Crème Brûlée: Beige-nude tint with a vanilla brown sugar scent


$110.00

Also, this essence helps to absorb all of my other skincare products better, so I’ve noticed when I use it in conjunction with my acne spot treatment, my pimple will clear up twice as fast. ...Best skin yet...This serum is the best of its kind. I’ve been using it for a week now and there’s no looking back.

What it is: A skincare-boosting treatment of 100 percent Hadasei-3™, a trio of fermented Japanese superfoods proven to hydrate, resurface, soften, and plump skin.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Fine Lines/Wrinkles, Dryness, and Dullness

Highlighted Ingredients:
- 100% Hadasei-3™, Tatcha’s Proprietary Complex of Rice, Green Tea, and Algae: Amino acids and AHAs (lactic acid) from double fermentation to resurface and plump.

Ingredient Callouts: This product is vegan, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: The Essence transforms your skin, both immediately and over time.

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“Have tried everything from drying lotion to sulfur treatments, this flattens out my pimple within 24 hours”
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“I used a squeeze of this formula on it and I woke up this morning, with not only the pain gone, but also the blemish. So in my experience, fast acting and complete relief! #freeproduct”