Best Treatments for Acne

Sephora customers often prefer the following products when searching for Best Treatments for Acne.

Dealing with acne can be frustrating and discouraging, but fear not – there are effective treatments available to help you achieve clear, radiant skin. Whether you're battling occasional breakouts or struggling with persistent acne, finding the right treatment can make all the difference. From over-the-counter remedies to at-home tools, this page is your ultimate guide to discovering the best treatments for acne. We'll explore various options that address different types of acne and provide valuable insights to help you make informed decisions on your journey towards a blemish-free complexion.

$65.00

This serum like treatment is so good it blew my minds. I used it for 3 nights and have already seen an improvement on my dark spots and acne marks. ...I received this treatment complimentary from peterthomasroth for my honest opinion....Best for acne scars

What it is: Now with a new look and potent Vitamin C, this is a cult-favorite Niacinamide treatment for expert-level brightening results. 


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Dark Spots, Dullness, and Uneven Texture


Formulation: Lightweight Cream


Highlighted Ingredients:
- Brightening Complex 15%: Brightens the look of discoloration, dark spots, and post-acne marks.

- THD Ascorbate Vitamin C: Is an ultra-stable form of vitamin C that boosts the visibly brightening effect.


Ingredient Callouts: Free of parabens, formaldehydes, fo

$68.00

Great product! I have been searching for a product that helps smooth my skin. I have been treating my skin for acne for years and it finally has cleared up. ...love this treatment!...This treatment is great. I have acne prone skin and love using retinol treatments on my face.

What it is: A high-potency dual retinoid formula delivers derm-level results for clear, luminous skin with minimal chance of irritation—no prescription needed.


Skin Type: Normal, Dry, Combination, and Oily


Skincare Concerns: Fine Lines and Wrinkles, Uneven Texture, and Acne and Blemishes


Formulation: Cream


Highlighted Ingredients:
- Retinaldehyde: Calcium encapsulated for advanced results with minimized irritation.

- Adapinoid: An oil-soluble retinoid that promotes clear-looking skin.

- Pomegranate Peel Extract: Supports healthy collagen production and soothes.

$25.00

Effective solution for acne...This product delivers as promised and is an effective solution for acne issues....direct treatment for acne spots...After using it for a few weeks I really like the formula, recommended #freeproduct

What it is: A targeted cream for acne spots that visibly reduces breakout size in as little as one hour.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Acne and Blemishes, and Oiliness

Highlighted Ingredients:
- 100% Natural Salicylic Acid: Naturally exfoliates and visibly refines skin texture.
- Niacinamide: Minimizes the appearance of pores.
- Tea Tree: Purifies the skin.

Ingredient Callouts: This product is vegan, gluten-free, and cruelty-free.

What Else You Need to Know: A natural and non-drying purifying cream that targets acne spots fast and reduce breakout size. Use this leave-on cream under makeup to color correct redness with natural green pigments.

$48.00

The BEST blemish treatment I have ever used...The best treatment I have used! The texture is light and silk, not sticky like others.

What it is: A liquid-suspension probiotic specifically designed for blemish-prone skin to significantly reduce the look of breakouts and blemishes and absorb excess sebum production.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Dark Spots, Uneven Texture, and Acne and Blemishes

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: This liquid-suspension probiotic is specifically designed for blemish-prone skin to significantly reduce the look of breakouts and blemishes and absorb excess sebum production.

Clinical Results: In a test, after 28 days, results showed:
- Inflammatory pustules reduced by 82%

$30.00

My Holy Grail for acne spot treatment....My Holy Grail for acne spot treatment!!! This reduced redness on and around the area of my acne. ...Thank you Skinfix for coming out with a line for acne!! This line was made for me and I absolutely love the ingredients that are in this spot treatment.

What it is: A clinical-strength, rapid-acting acne treatment that visibly reduces blemish size and redness plus helps prevent new acne pimples from forming.

Skin Type:
Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Redness, and Acne/Blemishes

Highlighted Ingredients:
- 2% Salicylic Acid: Decongests pores to help eliminate excess oil and surface debris.
- 10% Azelaic Acid: Helps fade the look of post-acne hyperpigmentation (acne marks/scars) while visibly improving uneven skin tone.
- 2% Niacinamide: Helps minimize the appearance of pores and regulate sebum.

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

$69.00

Awesome for acne...This product was gifted to me from Kate Somerville. This acne fading gel is wonderful! I’ve been using this product for about 4 days now, and I’m already seeing a difference in my acne marks. ...Suggested Treatment for Acne Prone skin...I have acne prone skin.I have been using it for 8 weeks.

What it is: A gel formula to prevent breakouts and visibly diminish post-acne marks in as little as three days while restoring the skin barrier.

Skin Type: Combination and Oily

Skincare Concerns: Pores, Uneven Texture, and Acne/Blemishes

Highlighted Ingredients:
- 2% Salicylic Acid: Diminishes the appearance of breakouts and prevents future acne.
- Prebiotic Complex: Balances and restores skin’s protective microbiome barrier.
- Niacinamide: Visibly evens skin tone from post-acne marks and improves the appearance of pores.

Ingredient Callouts: Free of parabens, phthalates, mineral oil, sulfates SLS & SLES, and contains less than one percent synthetic fragrance. It is also cruelty-free.

$48.00

BEST FOR ACNE...I used this acne treatment for a few days and I noticed BIG results!! ...Effective active treatment...Great retinol for acne prone skin. I love this mighty green retinol cream.

What it is: Experience the first-ever Adapinoid® retinoid for acne-prone skin proven to reduce blemishes while restoring skin barrier health.


Skin Type: Combination and Oily


Skincare Concerns: Pores, Acne/Blemishes, and Oiliness


Formulation: Lightweight Cream


Highlighted Ingredients:

- Adapinoid 0.16%: A brand new ingredient, this powerful retinoid helps reduce blemishes

- Niacinamide 2%: Is a potent antioxidant that absorbs oil and visibly reduces redness

- HydraSoothe: Helps to reduce discomfort, visible redness + boost hydration

$21.00

i love all of what Sephora do product wise especially for acne prone skin. Its such a good price point for good ingredients. ...This product is vegan, great for acne prone skin and suitable for any skin type.

What it is: An acne treatment gel that’s made with 98% ingredients from natural origin and is clinically suitable for acne-prone skin.

Skin Type: Normal, Combination, and Oily

Skincare Concerns: Pores, Acne and Blemishes, and Oiliness

Formulation: Lightweight Serum

Highlighted Ingredients:
- Salicylic Acid: Made from gaultheria leaves, it purifies and exfoliates.

Ingredient Callouts: This product is vegan.

What Else You Need to Know: This is an acne treatment gel made in accordance with a strict formulation charter. It includes 2% salicylic acid extracted from gaultheria leaves, known to purify the skin and effectively treat acne, the appearance of pores, blackheads, and sh

$35.00

I have oily, acne-prone skin and iNNBEAUTY PROJECT Acne Serum Medicated Treatment for Acne & Blackheads is gentle on my skin, doesn't feel greasy, and absorbs quickly. ...Solid serum for acne...It’s a nice mild serum for acne treatment. It has a lotion texture that mixes well with other serums.

What it is: A treatment that clears acne and blackheads fast while nourishing the skin's barrier.

Skin Type: Dry, Combination, and Oily

Skincare Concerns: Uneven Texture, Acne and Blemishes, and Oiliness

Highlighted Ingredients:
- 1.5% Salicylic Acid: FDA approved for the treatment of blemishes.
- 6% Skin Barrier Complex: Includes ceramides, lactobacillus ferment, and botanical extracts to support skin’s barrier and balance oil production.
- 4% Tranexamic Acid and Niacinamide: Visibly improves hyperpigmentation.

Ingredient Callouts: This product is vegan, gluten-free, cruelty-free, and comes in recyclable packaging.

What Else You Need to Know: This is an FDA-approved, non-drying, bl

$30.00

amazing for acne...Wonderful product for acne! I cut mine in half to be more cost effective. ...The best salicylic acid treatment...It doesn’t dry my skin out, but reduces my acne. It also saves me time from having to use a treatment I.

What it is: A daily facial pad that keeps breakouts at bay with maximum-strength, two percent salicylic acid, which is proven to target acne and new blemishes.

Skin Type: Normal, Dry, Combination, and Oily

Skincare Concerns: Pores, Oiliness, and Acne and Blemishes

Formulation: Wipes

Highlighted Ingredients:
- Salicylic Acid: Unclogs pores and targets breakouts.
- Kaolin Clay: Absorbs dirt, oil, and impurities from skin.
- Evermat: Mops up sebum, minimizes the appearance of pores, and absorbs oil.

Ingredient Callouts: This product is vegan, cruelty-free, and gluten-free, and comes in recyclable packaging.

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“I love Paula’s choice, this retinol treatment has transformed my skin, I feel like my texture and acne scars have diminished tremendously”
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“This treatment/serum has everything I need in a night treatment and has absolutely worked miracles for me”
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“I've struggled with adult acne for several years. I tried harsh treatments, I tried natural treatment, no real results”
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“this product combined with exfoliate exfoliating treatment changed my life after years of searching for a solution to my adult acne”